Finite Element Model of Mechanically Induced Collagen Fiber Synthesis and Degradation in the Aortic Valve
نویسندگان
چکیده
منابع مشابه
Computational analyses of mechanically induced collagen fiber remodeling in the aortic heart valve.
To optimize the mechanical properties and integrity of tissue-engineered aortic heart valves, it is necessary to gain insight into the effects of mechanical stimuli on the mechanical behavior of the tissue using mathematical models. In this study, a finite-element (FE) model is presented to relate changes in collagen fiber content and orientation to the mechanical loading condition within the e...
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In vitro mechanical conditioning has been demonstrated to be of critical importance in the tissue engineering of cardiovascular substitutes, i.e. vascular grafts and heart valves. Therefore, after static culturing, cell seeded constructs are placed in a bioreactor and subjected to pulsatile loading conditions. The objective is to stimulate cell proliferation and differentiation as well as extra...
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In bicuspid aortic valve (BAV) disease, the role of genetic and hemodynamic factors influencing ascending aortic pathology is controversial. To test the effect of BAV geometry on ascending aortic flow, a finite element analysis was undertaken. A surface model of aortic root and ascending aorta was obtained from magnetic resonance images of patients with BAV and tricuspid aortic valve using segm...
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Native aortic valve cusps are composed of collagen fibers embedded in their layers. Each valve cusp has its own distinctive fiber alignment with varying orientations and sizes of its fiber bundles. However, prior mechanical behavior models have not been able to account for the valve-specific collagen fiber networks (CFN) or for their differences between the cusps. This study investigates the in...
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A finite strain model for the mechanical degradation of composite materials with multiple families of fine reinforcing fibers is developed and studied. At any instant of time the matrix material may or may not be degrading with all, some, or none of the interpenetrating fibers also undergoing degradation. This multi-component description of damage is governed by coupled differential equations w...
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ژورنال
عنوان ژورنال: Annals of Biomedical Engineering
سال: 2003
ISSN: 0090-6964
DOI: 10.1114/1.1603749